Summary#
The final assigment for this course is for each student to prepare a 20 min presentation and a 10-page paper on a particular protein. Proteins of interest are listed here.
Motor Proteins#
F1/F0 ATPase
F1 ATPase (hint - not human)
V-type ATPase
Actin
Kinesin
Non-muscle myosin
Muscle Myosin
Ion Channels#
NaV1.5
NaV1.8
TRPV1
HCN1
Piezo
CFTR
IP3R
Transporters#
CLC
Na+/K+-ATPase
ABC Transporter (multidrug resistance)
EAAT1
Kinases#
Tyk2
BTK
EGFR
PKA
Abl
GPCRs#
Bacteriorhodopsin
Human rhodopsin
beta-2 Adrenergic Receptor
Opioid Receptor
mGluR
GLP-1R
Resources#
I’ve included here some reviews for the related protein families so you can get a sense of the kinds of articles you are looking for.
Review of AAA+ (Motor) Proteins
Dynein structure and power stroke
Structural biology and molecular pharmacology of voltage-gated ion channels
Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors
Chapter One - Catalytic Mechanisms and Regulation of Protein Kinases
G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery